赵丽娜课题组

学术新闻

03/03

2023

近年来,具有独特类酶催化性能的纳米酶引起了人们的极大关注。它们具有独特的优势,可以克服天然酶的难以储存、易变性和高成本等局限性。如何优化纳米酶的类酶催化活性、实现可控机制设计,并拓展其生物医学应用,成为重要的智能医学科学问题。本课题组针对L-半胱氨酸(L-Cys)自组装聚乙烯吡咯烷酮(PVP)修饰的Cu单原子纳米酶MoOx-Cu-Cys(MCCP-SAzymes)开展酶催化路径分子模拟与机制...

11/03

2021

与传统的分子药物相比,纳米药物通过改善其溶解性,肿瘤靶向性和延长血液循环时间等特性为药物开发提供了新的方向的思路。然而,纳米药物独特的表界面理化性质、不同的尺寸等使得目前的纳米药物进入临床所面临很多困难。近年来,自组装结构广泛地应用于药物递送、再生医学和免疫调节等领域,同时,如何在细胞内通过非共价键相互作用原位可控构建超分子结构并调控细胞命运,已经成为材料科学、化学生物学和分子医学等领域的前...

10/05

2021

Skin radiation damage is one of the most common illnesses in external beam radiotherapy. One of the vital reasons for the damage occurrence is the low-energy X-rays contained in treatment radiation...

07/09

2021

Nanomaterial-biology interaction is the critical step in the fate of biomedical nanomedicines, influencing the consequent biological outcomes. Herein, we present two-dimensional carbon-based nanoma...

06/03

2021

特邀报告人:孙少瑞,北京工业大学环境与生命学部环境化工系系主任,教授,博士生导师。

04/15

2021

Nanomaterials (NMs) as lung-targeted drug delivery vehicles have attracted great attentions. Recent studiesindicated that elastic or deformable property of NMs could play a vital role in biomedical...

02/22

2021

图1. 纳米蛋白冠介导的纳米材料“体内转运-生物转化-生物利用全过程”Many nanoscale biomaterials fail to reach the clinical trial stage due to a poor understanding of the fundamental principlesof their in vivo behaviour. Here we de...

01/20

2021

Metallofullerenes present an ideal research object for developing new carbon structures with improved properties under high pressure. In this study, high pressure investigation is realized on metal...

01/01

2021

Rationale: Most contemporary cancer therapeutic paradigms involve initial imaging as a treatment roadmap, followed by the active engagement of surgical operations. Current approved intraoperative c...

10/25

2020

Gastric environmentis anextremepH and enzyme-richcondition, whichtogether withgastricmucus barrier and short retention time of oral medicine militate against effective oral drug delivery to lesion ...

07/15

2020

Metalloenzymes are promising anticancer candidates to overcome chemoresistance by involving unique mechanisms. To date, it is still a great challenge to obtain synthetic metalloenzymes with persist...

07/13

2020

Multimodal nanoparticles for cancer theranostics
This issue highlights the stabilization of a brain–computer interface via the alignment of neural activity, nanoprobes for cancer theranostics,
综合新闻
日前,中科院高能物理研究所2023年所科技创新项目评审工作顺利结束,并完成公示。课题组赵丽娜老师申请的“物理嵌入机器学习驱动高能同步辐射物质解析新发现”,获得2023年度所科技创新资助,资助经费为120万元,资助年限为2023年-2025年。高能所科技创新项目是根据中科院“四个率先”、中科院创新规划及高能所战略目标需要,依据“总量控制、前瞻部署、引领发展、突出重点”的原则,高能所择优支持符合...
近日,中科院高能物理研究所2022年专业技术岗位分级聘用工作顺利结束,并完成公示。课题组伍力源老师通过竞聘晋升为副研究员。伍力源,2019年于北京邮电大学获得博士学位,2021年于北京邮电大学博士后出站后,加入中国科学院高能物理研究所多学科中心纳米生物效应组。主要研究方向为“多尺度模拟+机器学习”新范式解决新材料设计、药物研发等领域面临的分子模拟问题及关键科学问题。主持/参与国家自然科学基金...
2023年1月13日,中国科学院纳米生物效应与安全性重点实验室官网发布了《2022年度放华奖学金评选结果公示》,课题组徐德庭博士荣获“放华奖”。放华奖是高能所为引导和激发优秀年青人才投身于科学研究事业,加快培养我国放射化学与纳米生物医学相关学科领域的优秀青年科研人才所特设立优秀研究生奖学金,旨在奖励品学兼优、全面发展的在读研究生。该奖奖励对象主要为高能所在读的放射化学相关专业与纳米生物效应重...
文献评析
This 130-page “AI for Drug Discovery, Biomarker Development and Advanced R&D Landscape Overview 2020” report marks the ninth installment in a series of reports on the topic of the Arti...
‍‍Artificial Intelligence (AI) has recently started to gear-up its application in various sectors of the society with the pharmaceutical industry as a frontrunner beneficiary. This review highlights ...
We are pleased to introduce the Special Issue "Artificial Intelligence in Drug Discovery” highlighting the emerging role of artificial intelligence (AI) in pharmaceutical research. A focal point of...
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