赵丽娜课题组

学术新闻

03/03

2023

近年来,具有独特类酶催化性能的纳米酶引起了人们的极大关注。它们具有独特的优势,可以克服天然酶的难以储存、易变性和高成本等局限性。如何优化纳米酶的类酶催化活性、实现可控机制设计,并拓展其生物医学应用,成为重要的智能医学科学问题。本课题组针对L-半胱氨酸(L-Cys)自组装聚乙烯吡咯烷酮(PVP)修饰的Cu单原子纳米酶MoOx-Cu-Cys(MCCP-SAzymes)开展酶催化路径分子模拟与机制...

11/03

2021

与传统的分子药物相比,纳米药物通过改善其溶解性,肿瘤靶向性和延长血液循环时间等特性为药物开发提供了新的方向的思路。然而,纳米药物独特的表界面理化性质、不同的尺寸等使得目前的纳米药物进入临床所面临很多困难。近年来,自组装结构广泛地应用于药物递送、再生医学和免疫调节等领域,同时,如何在细胞内通过非共价键相互作用原位可控构建超分子结构并调控细胞命运,已经成为材料科学、化学生物学和分子医学等领域的前...

10/05

2021

Skin radiation damage is one of the most common illnesses in external beam radiotherapy. One of the vital reasons for the damage occurrence is the low-energy X-rays contained in treatment radiation...

07/09

2021

Nanomaterial-biology interaction is the critical step in the fate of biomedical nanomedicines, influencing the consequent biological outcomes. Herein, we present two-dimensional carbon-based nanoma...

06/03

2021

特邀报告人:孙少瑞,北京工业大学环境与生命学部环境化工系系主任,教授,博士生导师。

04/15

2021

Nanomaterials (NMs) as lung-targeted drug delivery vehicles have attracted great attentions. Recent studiesindicated that elastic or deformable property of NMs could play a vital role in biomedical...

02/22

2021

图1. 纳米蛋白冠介导的纳米材料“体内转运-生物转化-生物利用全过程”Many nanoscale biomaterials fail to reach the clinical trial stage due to a poor understanding of the fundamental principlesof their in vivo behaviour. Here we de...

01/20

2021

Metallofullerenes present an ideal research object for developing new carbon structures with improved properties under high pressure. In this study, high pressure investigation is realized on metal...

01/01

2021

Rationale: Most contemporary cancer therapeutic paradigms involve initial imaging as a treatment roadmap, followed by the active engagement of surgical operations. Current approved intraoperative c...

10/25

2020

Gastric environmentis anextremepH and enzyme-richcondition, whichtogether withgastricmucus barrier and short retention time of oral medicine militate against effective oral drug delivery to lesion ...

07/15

2020

Metalloenzymes are promising anticancer candidates to overcome chemoresistance by involving unique mechanisms. To date, it is still a great challenge to obtain synthetic metalloenzymes with persist...

07/13

2020

Multimodal nanoparticles for cancer theranostics
This issue highlights the stabilization of a brain–computer interface via the alignment of neural activity, nanoprobes for cancer theranostics,
综合新闻
2022年9月8日,国家自然科学基金委员会官网发布了《关于2022年国家自然科学基金集中接收申请项目评审结果的通告》,课题组的伍力源助理研究员申请的“基于机器学习势的新型杂化钙钛矿性能预测与验证”项目,获得国家自然科学基金青年科学基金项目的资助。资助期限为:2023年-2025年。 国家自然科学基金成立于1986年,旨在聚焦基础、前沿、人才,注重创新团队和学科交叉,为全面培育我国源头创新能...
中国机器学习与科学应用大会(CSML 2022)于2022年8月18日-19日在北京大学中关新园顺利举行。本次会议邀请了史作强副教授、王立威教授、吴昊教授、许志钦副教授、张林峰博士等五位知名学者做大会特邀报告,围绕机器学习辅助分子模拟的新进展、复杂度和泛化理论 、科学计算与机器学习等机器学习领域热点、前沿、难点问题分享了系统深入观点,有效促进了国内同行的学术交流和领域发展。 中科院高能物理所...
高能同步辐射光源(High Energy Photon Source, 简称HEPS)是《国家重大科技基础设施建设“十三五”规划》优先布局的十个重大科技基础设施之一,作为亚洲首个第四代同步辐射光源,也是中国第一个高能量的同步辐射光源,HEPS的建设将填补我国高能和第四代同步辐射装置的空白,为国家重大科技任务开展、工业核心能力提升、基础前沿科学发展提供先进的实验平台和基础条件支撑,是推动我国同...
文献评析
This 130-page “AI for Drug Discovery, Biomarker Development and Advanced R&D Landscape Overview 2020” report marks the ninth installment in a series of reports on the topic of the Arti...
‍‍Artificial Intelligence (AI) has recently started to gear-up its application in various sectors of the society with the pharmaceutical industry as a frontrunner beneficiary. This review highlights ...
We are pleased to introduce the Special Issue "Artificial Intelligence in Drug Discovery” highlighting the emerging role of artificial intelligence (AI) in pharmaceutical research. A focal point of...
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