赵丽娜课题组

学术新闻

03/03

2023

近年来,具有独特类酶催化性能的纳米酶引起了人们的极大关注。它们具有独特的优势,可以克服天然酶的难以储存、易变性和高成本等局限性。如何优化纳米酶的类酶催化活性、实现可控机制设计,并拓展其生物医学应用,成为重要的智能医学科学问题。本课题组针对L-半胱氨酸(L-Cys)自组装聚乙烯吡咯烷酮(PVP)修饰的Cu单原子纳米酶MoOx-Cu-Cys(MCCP-SAzymes)开展酶催化路径分子模拟与机制...

11/03

2021

与传统的分子药物相比,纳米药物通过改善其溶解性,肿瘤靶向性和延长血液循环时间等特性为药物开发提供了新的方向的思路。然而,纳米药物独特的表界面理化性质、不同的尺寸等使得目前的纳米药物进入临床所面临很多困难。近年来,自组装结构广泛地应用于药物递送、再生医学和免疫调节等领域,同时,如何在细胞内通过非共价键相互作用原位可控构建超分子结构并调控细胞命运,已经成为材料科学、化学生物学和分子医学等领域的前...

10/05

2021

Skin radiation damage is one of the most common illnesses in external beam radiotherapy. One of the vital reasons for the damage occurrence is the low-energy X-rays contained in treatment radiation...

07/09

2021

Nanomaterial-biology interaction is the critical step in the fate of biomedical nanomedicines, influencing the consequent biological outcomes. Herein, we present two-dimensional carbon-based nanoma...

06/03

2021

特邀报告人:孙少瑞,北京工业大学环境与生命学部环境化工系系主任,教授,博士生导师。

04/15

2021

Nanomaterials (NMs) as lung-targeted drug delivery vehicles have attracted great attentions. Recent studiesindicated that elastic or deformable property of NMs could play a vital role in biomedical...

02/22

2021

图1. 纳米蛋白冠介导的纳米材料“体内转运-生物转化-生物利用全过程”Many nanoscale biomaterials fail to reach the clinical trial stage due to a poor understanding of the fundamental principlesof their in vivo behaviour. Here we de...

01/20

2021

Metallofullerenes present an ideal research object for developing new carbon structures with improved properties under high pressure. In this study, high pressure investigation is realized on metal...

01/01

2021

Rationale: Most contemporary cancer therapeutic paradigms involve initial imaging as a treatment roadmap, followed by the active engagement of surgical operations. Current approved intraoperative c...

10/25

2020

Gastric environmentis anextremepH and enzyme-richcondition, whichtogether withgastricmucus barrier and short retention time of oral medicine militate against effective oral drug delivery to lesion ...

07/15

2020

Metalloenzymes are promising anticancer candidates to overcome chemoresistance by involving unique mechanisms. To date, it is still a great challenge to obtain synthetic metalloenzymes with persist...

07/13

2020

Multimodal nanoparticles for cancer theranostics
This issue highlights the stabilization of a brain–computer interface via the alignment of neural activity, nanoprobes for cancer theranostics,
综合新闻
北京最美时,又话毕业情。6月27日,AI分子课题组召开毕业欢送会,庆祝牛文超博士顺利毕业,会议由赵丽娜研究员主持,课题组全体成员参会。会上赵丽娜研究员为牛文超博士颁发了“持之以恒 醉心工作”奖杯,表达了对牛文超博士的肯定与赞许。当天恰逢牛文超博士生日,赵丽娜研究员及组会成员送给牛文超博士一份生日蛋糕,并送上了美好祝福。牛文超博士向赵丽娜研究员表达了深深的感谢与祝福,并祝愿AI分子课题组发展越...
按照科技部的要求,国家重点研发计划“纳米材料跨越生物屏障机制与效应调控方法”专项启动会于2022年6月2日上午9点以线上会议方式召开。会议由项目组负责人陈春英研究员主持召开,参会人员有四位院士在内的十余位专家组成员,科技部、纳米中心相关领导,以及负责项目四个课题的研究团队共计38人。会议主要有以下3项内容:1、领导致辞。国家纳米科学中心领导致欢迎辞,科技部和中科院领导发表讲话。2、项目汇报。...
课题组伍力源获得高能所2021年度谢家麟基金资助。高能所谢家麟基金设立是为了激励青年科技工作者以2011年度国家最高科学技术奖获得者谢家麟院士为榜样,继承老一辈科学家的优良传统,追求科学真理,追求学术卓越,加快青年科技骨干和学术梯队接班人的培养,保证高水平科技成果不断产出,推动高能所科研工作的持续稳定发展。谢家麟先生是中国科学院院士、国际著名加速器物理学家、2011年度国家最高科学技术奖获得...
文献评析
This 130-page “AI for Drug Discovery, Biomarker Development and Advanced R&D Landscape Overview 2020” report marks the ninth installment in a series of reports on the topic of the Arti...
‍‍Artificial Intelligence (AI) has recently started to gear-up its application in various sectors of the society with the pharmaceutical industry as a frontrunner beneficiary. This review highlights ...
We are pleased to introduce the Special Issue "Artificial Intelligence in Drug Discovery” highlighting the emerging role of artificial intelligence (AI) in pharmaceutical research. A focal point of...
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