赵丽娜课题组

学术新闻

03/03

2023

近年来,具有独特类酶催化性能的纳米酶引起了人们的极大关注。它们具有独特的优势,可以克服天然酶的难以储存、易变性和高成本等局限性。如何优化纳米酶的类酶催化活性、实现可控机制设计,并拓展其生物医学应用,成为重要的智能医学科学问题。本课题组针对L-半胱氨酸(L-Cys)自组装聚乙烯吡咯烷酮(PVP)修饰的Cu单原子纳米酶MoOx-Cu-Cys(MCCP-SAzymes)开展酶催化路径分子模拟与机制...

11/03

2021

与传统的分子药物相比,纳米药物通过改善其溶解性,肿瘤靶向性和延长血液循环时间等特性为药物开发提供了新的方向的思路。然而,纳米药物独特的表界面理化性质、不同的尺寸等使得目前的纳米药物进入临床所面临很多困难。近年来,自组装结构广泛地应用于药物递送、再生医学和免疫调节等领域,同时,如何在细胞内通过非共价键相互作用原位可控构建超分子结构并调控细胞命运,已经成为材料科学、化学生物学和分子医学等领域的前...

10/05

2021

Skin radiation damage is one of the most common illnesses in external beam radiotherapy. One of the vital reasons for the damage occurrence is the low-energy X-rays contained in treatment radiation...

07/09

2021

Nanomaterial-biology interaction is the critical step in the fate of biomedical nanomedicines, influencing the consequent biological outcomes. Herein, we present two-dimensional carbon-based nanoma...

06/03

2021

特邀报告人:孙少瑞,北京工业大学环境与生命学部环境化工系系主任,教授,博士生导师。

04/15

2021

Nanomaterials (NMs) as lung-targeted drug delivery vehicles have attracted great attentions. Recent studiesindicated that elastic or deformable property of NMs could play a vital role in biomedical...

02/22

2021

图1. 纳米蛋白冠介导的纳米材料“体内转运-生物转化-生物利用全过程”Many nanoscale biomaterials fail to reach the clinical trial stage due to a poor understanding of the fundamental principlesof their in vivo behaviour. Here we de...

01/20

2021

Metallofullerenes present an ideal research object for developing new carbon structures with improved properties under high pressure. In this study, high pressure investigation is realized on metal...

01/01

2021

Rationale: Most contemporary cancer therapeutic paradigms involve initial imaging as a treatment roadmap, followed by the active engagement of surgical operations. Current approved intraoperative c...

10/25

2020

Gastric environmentis anextremepH and enzyme-richcondition, whichtogether withgastricmucus barrier and short retention time of oral medicine militate against effective oral drug delivery to lesion ...

07/15

2020

Metalloenzymes are promising anticancer candidates to overcome chemoresistance by involving unique mechanisms. To date, it is still a great challenge to obtain synthetic metalloenzymes with persist...

07/13

2020

Multimodal nanoparticles for cancer theranostics
This issue highlights the stabilization of a brain–computer interface via the alignment of neural activity, nanoprobes for cancer theranostics,
综合新闻
10月19日上午,中科院高能所多学科中心党总支组织开展“线上科普 凝心聚力”系列活动的第五期——《现身说法话考核》。中心研究员赵丽娜为现场以及线上50余名同学做了精彩报告。
9月19日上午,多学科研究中心20余名导师在报告厅116会议室接待中国地质大学数理学院师生前来参观交流。
7月5日上午,中国地质大学万力副校长一行10余人到中科院高能所与多学科研究中心主任董宇辉签署了共建“学生培养实践基地”协议,并举行了揭牌仪式,党委书记魏龙出席揭牌仪式。
文献评析
This 130-page “AI for Drug Discovery, Biomarker Development and Advanced R&D Landscape Overview 2020” report marks the ninth installment in a series of reports on the topic of the Arti...
‍‍Artificial Intelligence (AI) has recently started to gear-up its application in various sectors of the society with the pharmaceutical industry as a frontrunner beneficiary. This review highlights ...
We are pleased to introduce the Special Issue "Artificial Intelligence in Drug Discovery” highlighting the emerging role of artificial intelligence (AI) in pharmaceutical research. A focal point of...
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