赵丽娜课题组

课题组发表Nature Nanotechnology论文——纳米材料钼酶

发表时间:2021-02-22 19:52

Nature Nanote.jpg

1. 纳米蛋白冠介导的纳米材料“体内转运-生物转化-生物利用全过程”

Many nanoscale biomaterials fail to reach the clinical trial stage due to a poor understanding of the fundamental principlesof their in vivo behaviour. Here we describe the transport, transformation and bioavailability of MoS2 nanomaterials througha combination of in vivo experiments and molecular dynamics simulations. We show that after intravenous injection molybdenum is significantly enriched in liver sinusoid and splenic red pulp. This biodistribution is mediated by protein coronas thatspontaneously form in the blood, principally with apolipoprotein E. The biotransformation of MoS2 leads to incorporation ofmolybdenum into molybdenum enzymes, which increases their specific activities in the liver, affecting its metabolism. Ourfindings reveal that nanomaterials undergo a protein corona-bridged transport–transformation–bioavailability chain in vivo,and suggest that nanomaterials consisting of essential trace elements may be converted into active biological molecules thatorganisms can exploit. Our results also indicate that the long-term biotransformation of nanomaterials may have an impact onliver metabolism.

国家纳米科学中心相关报道:http://www.nanoctr.cas.cn/zytp2017/202102/t20210222_5892822.html

原文链接:https://www.nature.com/articles/s41565-021-00856-w

Mingjing Cao#, Rong Cai#, Lina Zhao#, Mengyu Guo#, Liming Wang, Yucai Wang, Lili Zhang, Xiaofeng Wang, Haodong Yao, Chunyu Xie, Yalin Cong, Yong Guan, Xiayu Tao, Yaling Wang, Shaoxin Xu, Ying Liu, Yuliang Zhao & Chunying Chen*, Molybdenum derived from nanomaterials incorporates into molybdenum enzymes and affects their activities in vivo, Nature Nanotechnology 16, 708–716 (2021)

DOI:10.1038/s41565-021-00856-w


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