课题组发表Nano Today论文——磁石墨纳米胶囊

Gastric environmentis anextremepH and enzyme-richcondition, whichtogether withgastricmucus barrier and short retention time of oral medicine militate against effective oral drug delivery to lesion areasof gastric diseases. Assembly, especially shape-control assembly of magnetic nanoparticles potentiallyhelps the site-selective drug molecule delivery. However, the harsh gastric condition, and cumbersomeand strict requirements make the in situ reversible assembly remain challenging. Herein, synergisticallypepsin-bridged and magnetic field-mediated morphological control of magnetic-graphitic-nanocapsules(MGNs) needle assembly (MNA) is developed in stomach for prolonged gastric retention and enhancedmucus penetration. The MNAs with good biocompatibility, large magnetic moments and unique needleshape are formed with the help of pepsin, demonstrating superior magnetic-driven capability toovercome gastric mucus barrier. Molecular dynamics simulations reveal binding modes between MGNand amino acid residues on either side of the pepsin, indicating pepsin acts as “bridge” allowing sufficientcontact among MGNs and further facilitates the needle assembly. Moreover, anticancer drug doxorubicin(DOX)-loaded MNAs demonstrate superior targeted cancer cell killing ability and boosted DOX penetration in a mouse model, which promises good bioavailability of drug molecules. The versatile MNA-basedplatform offers a robust strategy for effective oral drug delivery and site-selective therapy of gastricdiseases.

DOI:10.1016/j.nantod.2020.101032